Endometriosis – Determinants of Oncogenesis (ENDO-ONC) Full Scale Study

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WHRI

Primary Contact: Heather Noga, Research Coordinator, 604-875-2424 ext 4924, Heather.Noga@cw.bc.ca 

About the study: The aim of this study is to determine whether there are unique genetic changes in endometriosis that may play a role in malignant transformation to ovarian cancer or in the symptoms of pelvic pain and infertility. This will be done by comparing surgical tissue samples from women with endometriosis to women without endometriosis.

Participants in this study agree to provide for research purposes: a saliva sample, tissue removed from their surgery, endometrial biopsy (a sample from the lining of the uterus – only if a sample is not already being removed for clinical purposes).

Why is this research important? Endometriosis affects 10% of reproductive aged women, causes pain and infertility, and is now known to also be associated with ovarian cancer. Studying gene mutations and expression changes in surgical tissue samples of women with or without endometriosis will help us understand how it can lead to pain, infertility, ovarian cancer, and other associated symptoms.

Study status: Recruitment and data collection is ongoing.

Who can participate: You have (or are suspected to have) endometriosis OR another benign gynaecological condition, You have chosen surgical treatment.

Co-Investigators: Dr. Catherine Allaire, Dr. Christina Williams, Dr. Mohamed Bedaiwy, Dr. Jessica McAlpine, Dr. David Huntsman.

Funded by: Canadian Institutes of Health Research (CIHR), Canadian Cancer Society Research Institute (CCSRI), Women’s Health Research Institute (WHRI)

Partners: Ovarian Cancer Research Group (OvCaRe), Centre for Translational and Applied Genomics (CTAG).

Clinic website: http://www.womenspelvicpainendo.com/

Clinic Research Page: http://www.womenspelvicpainendo.com/research/

Endometriosis – Determinants of Oncogenesis (ENDO-ONC)

Endometriosis – Determinants of Oncogenesis (ENDO-ONC)

Principal Investigator: Dr. Paul Yong

Primary Contact: Heather Noga, Research Coordinator, 604-875-2424 ext 4924, Heather.Noga@cw.bc.ca 

About the study: The aim of this study is to determine whether there are unique genetic changes in endometriosis that may play a role in malignant transformation to ovarian cancer or in the symptoms of pelvic pain and infertility. This will be done by comparing surgical tissue samples from women with endometriosis to women without endometriosis.

Participants in this study agree to provide for research purposes: a saliva sample, tissue removed from their surgery, and an endometrial biopsy (a sample from the lining of the uterus).

Why is this research important? Endometriosis affects 10% of reproductive aged women, causes pain and infertility, and is now known to also be associated with ovarian cancer. Studying gene mutations and expression changes in surgical tissue samples of women with or without endometriosis will help us understand how it can lead to pain, infertility, ovarian cancer, and other associated symptoms.

Study status: Recruitment and data collection is ongoing.

Who can participate: You have (or are suspected to have) endometriosis OR another benign gynaecological condition and have chosen surgical treatment at the BC Women’s Center for Pelvic Pain and Endometriosis.

Co-Investigators: Dr. Catherine Allaire, Dr. Christina Williams, Dr. Mohamed Bedaiwy, Dr. Jessica McAlpine, Dr. David Huntsman, Dr. Michael Anglesio.

Funded by: Canadian Institutes of Health Research (CIHR), Canadian Cancer Society Research Institute (CCSRI), Women’s Health Research Institute (WHRI)

Partners: Ovarian Cancer Research Group (OvCaRe), Centre for Translational and Applied Genomics (CTAG), Women’s Health Research Institute, BC Children’s Research Institute.

Study results/publications:

Somatic Cancer-Driver Alterations Among Benign Endometriosis Subtypes
Lac V, Aguirre-Hernandez R, Tessier-Cloutier B, Orr N, Noga H, Lum A, Prentice L, Khattra J, Nazeran T, Co D, Praetorius T, Senz J, Kobel M, Kommoss S, Kommoss F, Yong P, Anglesio M, & Huntsman D. Modern Pathology. 31; 432-433, 2018

Cancer-associated mutations in non cancer-associated endometriosis.
Anglesio MS, **Papadopoulos N, Ayhan A, Nazeran TM, Noë M, Horlings HM, Lum A, Jones S, Senz J, Seckin T, Ho J, Wu RC, Lac V, Ogawa H, Tessier-Cloutier B, Alhassan R, Wang A, Wang Y, Cohen JD, Wong F, Hasanovic A, Orr N, Zhang M, Popoli M, McMahon W, Wood LD, Mattox A, Allaire C, Segars J, Williams C, Tomasetti C, Boyd N, Kinzler KW, Gilks CB, Diaz L, Wang TL, Vogelstein B, **Yong PJ, **Huntsman DG, **Shih I-M. ** = co-senior authors.
New England Journal of Medicine, (2017), 376(19):1835-1848.
DOI: 10.1056/NEJMoa1614814

Nerve growth factor and sexual pain in endometriosis.
Peng B, Zhan H, Alotaibi F, Alkusayer G, Bedaiwy MA, Yong PJ.
Reproductive Sciences, 2017. Advance Online Access.
Doi: 10.1177/1933719117716778

Anatomic sites and associated clinical factors for deep dyspareunia.
Yong PJ, Williams C, Yosef A, Wong F, Bedaiwy MA, Lisonkova S, Allaire C.
Sexual Medicine, 2017 Sep;5(3):e184-e195.
Doi: 10.1016/j.esxm.2017.07.001

Clinic website: http://www.womenspelvicpainendo.com/

Clinic Research: http://www.womenspelvicpainendo.com/research/

Yong Lab: http://yonglab.med.ubc.ca/

The Women’s Health Research Institute would like to acknowledge that we are uninvited guests on the unceded ancestral territories of the xʷməθkwəy̓əm (Musqueam), Skwxwú7mesh (Squamish), Stó:lo, and sel̓íl̓witulh (Tsleil-waututh) Nations.

As a provincial research institute committed to improving the health outcomes of women, including those across the 2SLGBTQIA+ spectrum, we recognize our responsibility in the collective effort towards establishing culturally safe health care systems and services that address health inequities among Indigenous peoples, especially Indigenous women, girls, and Two-spirit peoples.

We encourage all people involved in research to read both the Truth and Reconciliation Commission of Canada: Calls to Action and the In Plain Sight Report, and reflect on ways we can incorporate the recommendations into our work. As we gather in spaces together, we encourage you to reflect on your positionality on these lands and your personal commitments to reconciliation.

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