Infection And PPROM STudy

Pregnant Women with PPROM Needed

Preterm Premature Rupture Of the Membranes (PPROM) occurs before 20-55% of all preterm deliveries, and is the leading identified cause of preterm birth. Because preterm birth can lead to negative health consequences for the baby, it is important to prevent and treat PPROM. While we know that changes in the bacterial balance and infections are associated PPROM, we do not know which bacteria lead to these infections, and therefore PPROM can be difficult to treat. The goal of this study is to use new laboratory techniques to understand what bacteria are present in the vagina of women diagnosed with PPROM.

Who can participate?

You may be eligible to participate in the study if:

• you are diagnosed with PPROM between 24 and 34 weeks gestation
• you are having a single baby
• your baby has not been diagnosed with any major anomaly or genetic syndrome
• there is no reason for preterm birth other than PPROM (e.g. high blood pressure)

What does participation involve?

• During assessment for PPROM, you will undergo a speculum exam during which several vaginal swabs will be taken. You will undergo this exam regardless of your participation in this study. If you do choose to participate, 2 additional swabs will be taken. This should not add any time or discomfort to the exam.
• If you choose to participate in the study, the research assistant will ask you some questions about your medical history. All information will be kept confidential.
• If you do not deliver your baby immediately following PPROM, either you or a doctor will be asked to take 3 study swabs every 7 days until you deliver.
• When you deliver your baby, you will again have a speculum exam, and 3 study swabs will be taken in the same way as in the first exam.

How do you participate in this study?

If you are interested in participating, contact the PPROM Study Coordinator,

Danielle Bourque at 604-875-2424 ext 4873 or dbourque@cw.bc.ca.